Dr Matt Kaeberlein

Optispan is a vision for what health should be.

The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good.

We believe that the current practice of medicine is disease care, not health care. We believe that everyone can get closer to their own optimal healthspan.

Join us on a journey of discovery as we explore the science of longevity and optimal healthspan ("Optispan"). The journey is the reward.

We hope you find this content valuable, join by subscribing to the channel, and come back often. More importantly, we hope that you apply what you learn here to recover your lost decade, and perhaps much more.



Dr Matt Kaeberlein

My Top Supplements for Strength and Health

8 hours ago | [YT] | 8

Dr Matt Kaeberlein

Creatine

Do resistance training with creatine. I take five grams per day and have been doing so for a while. There’s really solid evidence that 3–5 grams per day, combined with regular resistance training, significantly improves body composition compared to training alone.

Omega-3

You want to measure your levels and get into the optimal range. I aim for an omega index above 8%, taking 1,300 mg per day. Test first, and then supplement later to hit the optimal range

Vitamin D

Same story: measure first, then supplement to hit your optimal range. I aim for 50–60 ng/dL. It usually takes about three months to reach a steady-state level, so plan ahead.

Lithium Orotate

You want to look at low-dose lithium orotate, not prescription lithium. The epidemiology data from drinking water show lower all-cause mortality and protection against dementia. I take 10 mg per day. The risk/reward looks favorable, especially for long-term brain health.

14 hours ago | [YT] | 41

Dr Matt Kaeberlein

Where do you stand on NAD+ boosters (NMN/NR)?

3 days ago | [YT] | 3

Dr Matt Kaeberlein

That’s the real secret to effortlessly look good

3 days ago | [YT] | 9

Dr Matt Kaeberlein

Shannon Anderson learned that when you feel good and are healthy on the inside, it shows on the outside.

That’s the real secret.

It doesn’t work from the outside in, it works from the inside out.

Most days, she’s camera-ready with no makeup and no hair color.

All she does is comb her hair, wash her face, and put on a little lotion, and she’s ready to go anywhere.

When she looks at photos of herself now, she notices it immediately: her health is showing. And she feels great.

So if you’re a little vain, she says this is actually the shortcut to looking good.

Chasing external fixes while neglecting your health from the inside never works.

4 days ago | [YT] | 12

Dr Matt Kaeberlein

One of the greatest gifts aging gave her was clarity.

5 days ago | [YT] | 4

Dr Matt Kaeberlein

One of the greatest gifts aging gave her was clarity.

At some point, what was happening inside began to show on the outside, and no amount of surface fixes could hide it.

Shanon saw a photo from five years ago: dyed hair to cover the gray, exaggerated lashes, expensive clothes tailored to hold everything together.

When she looked at it, she thought she looked like clown

That was the moment she realized the things she was doing “in the name of health” weren’t working anymore.

She could keep painting over the problem, or finally fix it from the inside out.

6 days ago | [YT] | 9

Dr Matt Kaeberlein

"I always mistook good health for good looks. I figured if I looked good, then I would feel good."

This week's guest, Shannon Anderson, spent decades chasing the body ideals of the Jane Fonda and Madonna eras, until her body and brain started to fail her in her 50s.

Her 5-year journey to true health is one of the most honest and relatable talks we've shared.

She talks about eating disorders, hormone therapy myths, finding the right trainer, and how the ultimate "beauty hack" has nothing to do with makeup.

Watch the episode now!

1 week ago | [YT] | 12

Dr Matt Kaeberlein

For years, she believed that looking thin meant being healthy

1 week ago | [YT] | 9

Dr Matt Kaeberlein

Many of us grew up believing good looks meant good health, and society reinforced that idea.

In her era, Jane Fonda represented the ideal of health.

But looking back, shannon realizes that the ideal was deeply unhealthy.

Fonda has spoken openly about disordered eating, and at the time, she didn’t even have language for what she herself was doing.

They were all chasing the same image: thin, under-muscled, and mistaken for healthy.

1 week ago | [YT] | 25