Nanomedicine and Nanomaterial Customization

NIR-II Breakthrough in Bone Marrow-Targeted mRNA Delivery
(1) Journal Source:
Journal of the American Chemical Society (JACS)
(2) Article Title:
BODIPY-doped Nanocarrier Engineering (BONE) Enhances Bone Marrow mRNA Delivery via NIR-II Bioimaging-Guided Screening
(3) Research Concept:
This study devises a BODIPY-doped Nanocarrier Engineering (BONE) strategy, leveraging NIR-II bioimaging technology to guide the development and screening of a bone marrow-targeted mRNA delivery system, encompassing both in vitro construction and in vivo evaluation pipelines.
(4) Material Development:
Materials: Lipid Nanoparticles (LNPs) doped with a NIR-II-emissive BODIPY dye.
Function: Construction of bone-targeted LNPs, enabling bone marrow-specific mRNA delivery and the visualization of targeting efficiency.
(5) Innovation Highlights:
Innovatively integrates NIR-II imaging for in situ, non-invasive, and real-time visualization, establishing a generalizable framework for the screening of tissue-specific nanocarriers.
#NIRIIImaging #mRNAdelivery #Nanomedicine #BoneMarrowTargeting #LipidNanoparticles #JACS #BODIPY #PrecisionMedicine

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7 hours ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Breakthrough in Cryogel Models! Recreating Early Signals of Breast Cancer Bone Metastasis
Journal Source:
Advanced Science
Article Title:
Mineralized Cryogel/Hydrogel Constructs for Recapitulating Early-Stage Breast Cancer Bone Metastasis in Vitro
Research Concept:
This study designs a biphasic hydrogel model system (integrating a nanoporous hydrogel phase and macroporous cryogel chambers) to accurately recapitulate the key structural, biophysical, and biochemical characteristics of the bone microenvironment in vitro. The system is engineered to investigate the seeding behavior of breast cancer cells during the initial stages of bone metastasis. It tracks the spatiotemporal distribution and response mechanisms of cancer cells under varying conditions, with a specific focus on cell invasion, matrix interactions, and proliferation processes, thereby elucidating the impact of microenvironmental cues on the metastatic cascade.
Material Development:
Materials: A nanoporous hydrogel phase based on glycosaminoglycans, combined with macroporous cryogels.
Function: The cryogel chambers are precisely functionalized with bone-mimetic biomolecular signals (e.g., adhesion peptides) and mineral crystals, while the hydrogel phase embeds cancer cells for real-time dynamic monitoring of cellular behavior. The system simulates the microenvironmental cues that guide cell invasion, changes in gene expression, and survival/proliferation dynamics. Tunable parameters (e.g., crosslinking density) enable the targeted experimental recapitulation of specific conditions.
Innovation Highlights:
This system represents the first highly biomimetic in vitro model of bone metastasis, overcoming the limitations of existing technologies. By integrating structural components and biological signals, it enables the efficient dissection of the interactions between cell behavior and the microenvironment. This work establishes a novel platform for deepening the understanding of early metastatic mechanisms and for screening candidate therapeutic agents, while circumventing the inherent variability and ethical constraints associated with in vivo models.
#BreastCancerResearch #BoneMetastasis #Hydrogel #Cryogel #TumorMicroenvironment #InVitroModel #RegenerativeMedicine #AdvancedScience

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1 day ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Printable Hydrogel Sensors: A New Breakthrough in Postoperative Blood Flow Monitoring
(1) Journal Source:
National Science Review
(2) Article Title:
Flexible electronics with printable responsive hydrogel interfaces for detecting blood circulation complications
(3) Research Concept:
This study designs a soft biosensor based on a printable thermoresponsive hydrogel interface for monitoring blood circulation complications in postoperative free flaps. By developing a hydrogel interface with tunable adhesion, the sensor achieves tight coupling with the skin during monitoring to acquire high-quality signals, and enables gentle peeling after monitoring to avoid tissue damage. The sensor utilizes an 810 nm light source to capture photoplethysmography (PPG) signals and introduces a Balance Index to distinguish between venous congestion and arterial insufficiency.
(4) Material Development:
Materials: A thermoresponsive hydrogel based on N-isopropylacrylamide (NIPAM) and zwitterionic monomers. Cellulose nanofibers are added to adjust the rheological properties, enabling direct printing and molding.
Function: Features temperature-triggered adhesion modulation. Strong adhesion at room temperature ensures stable signal acquisition, while reduced adhesion upon heating allows for non-invasive, damage-free removal.
(5) Innovation Highlights:
A printable hydrogel interface with tunable adhesion for coupling flexible electronics with biological tissues.
Utilization of an isosbestic point wavelength light source to eliminate interference from blood oxygen level changes in perfusion index calculations.
Definition of a Balance Index for the quantitative detection and waveform recognition of venous congestion.
Integration of temperature sensing and PPG detection for differentiating multi-parameter blood flow complications.
#BiomedicalEngineering #FlexibleElectronics #HydrogelSensor #PostoperativeCare #TissueEngineering #Nanomedicine #BloodFlowMonitoring

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2 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Advanced Functional Materials | Thermoplastic Bone Scaffold: A Breakthrough in Hemostasis and Osteogenesis

(1) Journal Source
Advanced Functional Materials

(2) Title
Thermoplastic and Trackable Bone Scaffold Dynamically Enhances Hemostasis and Osteogenesis in Bone Defects

(3) Research Insight
Inspired by the natural structure of bone and the plasticity of beeswax, this study designs a thermally adaptive and non‑invasively trackable bone scaffold (TRANS). By integrating thermally sensitive, CT‑trackable ichthyoid chitosan derivative (IQCH) with nano‑hydroxyapatite (nHA) and infiltrating it with a beeswax‑like molecule (PEG), the scaffold achieves dynamic reshaping, restoration of mechanical strength and porous structure. It comprehensively promotes hemostasis, stem cell infiltration, osteogenic differentiation, and enables real‑time imaging.

(4) Material Development
🧪 Material:

IQCH (ichthyoid chitosan derivative, thermally sensitive and CT‑trackable).

nHA (nano‑hydroxyapatite).

PEG (polyethylene glycol, beeswax‑like molecule).
⚙️ Functions:

Thermoplasticity: Becomes pliable when heated to conform to irregular defects, and hardens upon cooling to provide stable hemostasis.

CT‑Trackability: Allows for non‑invasive monitoring.

Dynamic Porosity Restoration: Absorbs PEG to dynamically restore its porous structure, promoting cell infiltration and differentiation.

(5) Key Innovations
🔬 Integrated Multifunctional Scaffold: Develops a biomimetic, thermoplastic, and trackable scaffold that dynamically integrates hemostasis, osteogenesis, and real‑time imaging functions in a single platform.
🔄 Simplified Clinical Procedure: Avoids the complexity of multi‑stage surgeries by combining critical functions, offering a new conceptual approach for bone defect repair research.

🛎️ Suggested Hashtags
#BoneScaffold #Thermoplastic #Hemostasis #Osteogenesis #CTImaging #AdvancedFunctionalMaterials #TissueEngineering #BoneRegeneration #Biomaterials #RegenerativeMedicine

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3 days ago | [YT] | 3

Nanomedicine and Nanomaterial Customization

Advanced Science | Mechanical Overload Disrupts Nanocrystals! The Mysterious Culprit of Arthritis Unveiled

(1) Journal Source
Advanced Science

(2) Title
Mechanical Overload‑Induced Nanomineral Crystal Perturbation at the Osteochondral Interface: A Potential Trigger for Osteoarthritis

(3) Research Insight
This study investigates the pathological mechanisms of osteoarthritis (OA), focusing on the perturbation of nanomineral crystals at the osteochondral interface induced by mechanical overload. Researchers observed that mechanical overload causes nanocrystal fragmentation and ectopic deposition, increasing extracellular matrix stiffness, which in turn promotes chondrocyte hypertrophy and the secretion of mineralized vesicles. This establishes a vicious cycle that accelerates tissue mineralization and degeneration. Experiments show that removing the mechanical overload can block this process and reverse pathological progression.

(4) Material Development
🧪 Material: The study did not involve the development of new materials; it was primarily based on biomedical samples of extracellular matrix and natural nanomineral crystals.
⚙️ Function: Not applicable (the research focuses on pathological mechanisms, not functional material design).

(5) Key Innovations
🔬 First Identification of a Primary Trigger: Proposes, for the first time, that nanomineral crystal perturbation is an original triggering event in osteoarthritis.
🔄 Revealed a Nanoscale Pathological Cycle: Uncovers the mechanism of a mechanical overload‑induced nanoscale pathological vicious cycle, providing a novel perspective for a deeper understanding of OA progression.

🛎️ Suggested Hashtags
#Osteoarthritis #Nanocrystals #MechanicalOverload #Cartilage #AdvancedScience #Pathology #BoneResearch #TissueDegeneration #Biomechanics #MedicalResearch

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4 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Smart Dressing: A New Revolution in Wound Self‑Healing

(1) Journal Source
Advanced Functional Materials

(2) Title
Self‑Powered, Breathable Electronic Dressing for Exudate Management, Electrical Stimulation, and Drug Delivery in Chronic Wound Healing

(3) Research Insight
This study designs a self‑powered breathable electronic dressing (SPED) that synergistically integrates exudate management, electrical stimulation therapy, and drug delivery functions. It aims to address the core challenges in chronic wounds, such as excessive exudation, bacterial infection, and persistent inflammation, thereby accelerating the wound healing process.

(4) Material Development
🧪 Material: Comprises a Janus fiber substrate with asymmetric wettability, a triboelectric nanogenerator embedded in a liquid metal circuit, and conductive microneedles loaded with antibacterial drugs.
⚙️ Functions:

Enables unidirectional exudate drainage.

Provides self‑powered electrical stimulation therapy.

Achieves on‑demand drug release.

(5) Key Innovations
⚡ Integrated Multifunctional Platform: Innovatively integrates autonomous energy harvesting, intelligent fluid management, and precise treatment into a single wearable system.
🔄 New Paradigm for Wound Care: Establishes a novel paradigm of bioelectronic wound care for the treatment of chronic wounds.

🛎️ Suggested Hashtags
#SmartDressing #WoundHealing #SelfPowered #Bioelectronics #ChronicWounds #ElectricalStimulation #DrugDelivery #AdvancedFunctionalMaterials #Nanogenerator #WearableTech

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5 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | New Osteoporosis Mechanism: GSS Methylation Drives Disease, Targeted GSH Reverses It

(1) Journal Source
Bioactive Materials

(2) Title
Age‑associated GSS promoter methylation in BMSCs drives osteoporosis and is reversed by targeted GSH delivery

(3) Research Insight
This study investigates the underlying cause of age‑associated osteoporosis, finding that DNA methylation‑mediated inhibition of glutathione synthetase (GSS) is an upstream lesion. This inhibits endogenous glutathione (GSH) synthesis in aged bone, thereby reducing osteoblast differentiation capacity. By developing a targeted GSH delivery platform, the researchers aim to reverse this metabolic defect and restore osteogenic function.

(4) Material Development
🧪 Material: An exosome‑based GSH delivery platform. GSH is efficiently loaded via electroporation into exosomes derived from CXCR4‑enriched bone marrow mesenchymal stem cells (BMSCs).
⚙️ Functions:

Achieves bone marrow niche targeting via CXCR4 mediation.

Enhances bone retention and stabilizes GSH during loading and circulation.

Elevates the local GSH pool at osteogenic sites.

(5) Key Innovations
🔬 Mechanistic Insight: Reveals the mechanism by which DNA methylation restricts GSH synthesis upstream in aging bone.
🚀 Therapeutic Platform: Innovatively develops a bone‑homing exosome‑mediated targeted GSH delivery system.
🛡️ Functional Recovery: Effectively ameliorates oxidative stress and mitochondrial dysfunction, promoting osteogenesis.

🛎️ Suggested Hashtags
#Osteoporosis #DNAMethylation #Glutathione #Exosomes #TargetedDrugDelivery #BoneRegeneration #Aging #OxidativeStress #BioactiveMaterials #StemCells

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6 days ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | Bioinspired Microspheres: A New Breakthrough in Alveolar Bone Regeneration

(1) Journal Source
Bioactive Materials (IF 20.3)

(2) Title
Assembled Bioinspired Multifunctional Microspheres for Enhanced Alveolar Bone Regeneration

(3) Research Insight
This study designs a bioinspired multifunctional microsphere system aimed at addressing the challenges of the complex oral microenvironment and the coordinated restoration of multiple tissues during alveolar bone regeneration. By integrating biomimetic strategies, the system optimizes selective stem cell binding and osteoinductive capacity, thereby promoting effective regeneration of periodontal tissues.

(4) Material Development
🧪 Material: UV‑assembled nanofiber‑hollow microspheres (NFH‑MS).
⚙️ Functions:

Possesses injectability and robust mechanical structure.

Enables specific binding to bone marrow‑derived stem cells (BMSCs).

Exhibits strong osteoinductive properties, supporting cell infiltration and biomineralization.

(5) Key Innovations
🔬 Enhanced Structural Integrity via UV‑Assembly: UV‑assembly technology improves the mechanical integrity and pore interconnectivity of the microspheres.
🎯 Dual‑Peptide Functionalization: Incorporates the E7 peptide for targeted BMSC binding and encapsulates a bone‑forming peptide (BFP) in the core.
⬆️ Upregulation of Cell Adhesion & Differentiation: Significantly upregulates connexin 43 and N‑cadherin expression, enhancing cell adhesion, osteogenic differentiation, and mineralization processes.

🛎️ Suggested Hashtags
#AlveolarBoneRegeneration #BioinspiredMicrospheres #StemCells #Biomaterials #TissueEngineering #BioactiveMaterials #Osteoinduction #DentalImplants #BoneRegrowth #RegenerativeMedicine

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

Bioactive Materials | γ‑USCs Combined with SIS Hydrogel for Immunomodulatory Scar‑Free Healing

(1) Journal Source
Bioactive Materials (DOI: 10.1016/j.bioactmat.2025.12.010)

(2) Title
IFN‑γ‑licensed urine‑derived stem cells incorporated in SIS hydrogel promote scar‑free wound healing via immunomodulation and microenvironment remodeling

(3) Research Insight
This study designs an innovative strategy using IFN‑γ‑pretreated urine‑derived stem cells (γ‑USCs) encapsulated in a small intestinal submucosa (SIS) hydrogel. Through immunomodulation and microenvironment remodeling, it promotes scar‑free healing of skin wounds. The research systematically investigates the enhanced immunomodulatory properties of γ‑USCs, including their ability to drive macrophage polarization toward an anti‑inflammatory phenotype, and validates their inhibitory effect on fibrotic responses in both in vitro and in vivo models.

(4) Material Development
🧪 Material: IFN‑γ‑pretreated urine‑derived stem cells (γ‑USCs) and SIS hydrogel.
⚙️ Functions:

γ‑USCs exhibit enhanced immunomodulatory capacity, inhibiting the activation of fibrosis‑related cells.

SIS hydrogel provides a supportive microenvironment, facilitating tissue repair and collagen remodeling.

(5) Key Innovations
🔬 Synergistic Combination Strategy: Innovatively combines IFN‑γ‑licensed USCs with the biomaterial SIS hydrogel to synergistically regulate the immune microenvironment.
🛡️ Effective Fibrosis Suppression: Demonstrates effective suppression of persistent fibrotic responses, offering a novel strategy for scar‑free wound healing.

🛎️ Suggested Hashtags
#ScarFreeHealing #Immunomodulation #StemCellTherapy #SISHydrogel #WoundHealing #BioactiveMaterials #TissueRegeneration #Fibrosis #AntiInflammatory #RegenerativeMedicine

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1 week ago | [YT] | 0

Nanomedicine and Nanomaterial Customization

The Journal of Clinical Investigation | Lymphatics Drive Bone Regeneration Breakthrough

(1) Journal Source
The Journal of Clinical Investigation

(2) Title
Lymphatics foster bone regeneration by enhancing osteoclast activity in a murine amputation model

(3) Research Insight
This study tests the hypothesis that lymphatic vessels modulate regenerative capacity using a murine amputation model. It finds that lymphatic vessels grow toward and surround bone tissue post‑amputation. Inhibition of lymphangiogenesis—via genetic, pharmacological, or surgical means—enhances osteoclast activity, accelerates bone resorption, and leads to more robust regeneration.

(4) Material Development
🧪 Material: Lymphatic system‑specific reporter mouse line.
⚙️ Function: Used to track the dynamic behavior of lymphatic vessels during homeostasis and following amputation.

(5) Key Innovations
🔬 Novel Regulatory Mechanism: Reveals a new mechanism whereby lymphatic vessels promote bone regeneration by modulating immune cell dynamics and osteoclast function, providing a key mechanistic link in understanding regenerative processes.

#BoneRegeneration #Lymphatics #Osteoclast #TissueRegeneration #JCI #AmputationModel #Lymphangiogenesis #Immunology #SkeletalBiology #RegenerativeMedicine

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1 week ago | [YT] | 0